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one

yesterday’s article unexpectedly became one of the few hot-selling articles of mine recently. this shows that topics about medicine and health are one of the most merged similar items in people’s minds.

of course, there are different voices. for example, a person who claims to be a medical professional questioned me, saying that you use your friend's individual example to prove that domestic generic drugs are not good. isn't that generalizing based on a limited example? how convincing is it?

however, judging from more comments, my friend's child's experience of being cheated by domestic generic drugs is not an isolated case.

the rampant falsification of clinical data in china directly threatens the safety of every patient. (photo by nong jian) ​​source: southern weekend

i need to state here that i am not blindly praising imported drugs while blindly criticizing domestic generic drugs. i am not a medical professional and lack the necessary knowledge in this area. i just make judgments and choices based on my common sense and logic, and such judgments and choices have been verified to be correct by countless people.

the emergence of domestic generic drugs certainly brings many benefits, such as it can break the price monopoly of imported drugs and benefit patients.

however, for patients, curing the disease is the first priority. otherwise, no matter how cheap the medicine is, it will not only be meaningless, but may also delay the disease and harm the body.

some media outlets really don’t need to keep complaining about consumers using a “beautification filter” when it comes to imported drugs. instead, they should speak out louder about how to improve the quality of domestic drugs and prevent them from harming public health.

two

why do many people not trust domestic medicines?

because such trust has been eroded by one vicious case after another and by shocking falsified data.

remember the rabies vaccine incident that year?

on july 15, 2018, the state food and drug administration issued a notice stating that changchun changsheng biotechnology co., ltd. had falsified records in the production of freeze-dried human rabies vaccines. this was the second time the company had been exposed to vaccine quality issues less than a year after it was found in november 2017 that the potency index of the diphtheria, pertussis and tetanus vaccine did not meet regulations.

according to subsequent media reports, changsheng did not simply record the production cost this time, but used larger fermentation tanks that did not meet the production process to carry out prodrug fermentation, and then compiled it into batches that met the production standards of fermentation tanks.

this is fake medicine, it's no exaggeration.

what is rabies? it is a zoonotic infectious disease caused by the rabies virus that mainly invades the central nervous system. after being infected with the virus, clinical manifestations may include fear of water, fear of wind, pharyngeal muscle spasm, which can lead to paralysis of respiratory muscles after spasm, and often death from respiratory failure. the terrifying thing is that the mortality rate of rabies is as high as 100%. in other words, the only guarantee after a person is bitten is to get a rabies vaccine.

however, under such circumstances, some people actually dared to falsify this vaccine. this is a typical case of murder for money!

an online search revealed that there have been incidents of using saline solution to impersonate rabies vaccines in many places.

how cruel must one be to put others in a life-and-death situation for a little profit?

by the way, the rabies vaccine virbac was the first imported vaccine in china and was approved in 1994.

at that time, china's domestically produced rabies vaccines were mainly hamster kidney cell vaccines from the 1980s, which had a short validity period, late antibody production, early disappearance, and low positive conversion rate. therefore, vero became the best rabies vaccine in china at that time. as early as 1987, the world health organization issued the vero cell production of human rabies vaccine regulations, recommending the use of vero cells for mass production of rabies vaccines.

however, "the last batch issuance record of virbac was in june 2010, when 10 batches of 1.05 million doses were approved that month." the last batch issuance record of another imported rabies vaccine, rebipro, was in november 2018, when 8 batches of 680,000 doses were approved that month.

it is said - i have not verified it - that if you are accidentally bitten by a dog now, you can only get domestic vaccines.

be sure to take care of yourself and take good protection.

three

let’s talk about the falsification of new drug trial data.

according to southern weekend, "on november 11, 2015, the state food and drug administration issued an announcement stating that during an on-site inspection of some drug registration applications, it was found that the clinical trial data of 11 drug registration applications from 8 companies were untrue and incomplete. the decision was made not to approve their registration applications, and for the first time, the list of the pharmaceutical companies, clinical trial institutions and cro companies involved was exposed."

you should know that the results of clinical trials of drugs are not only the only criterion for testing the safety and effectiveness of drugs, but also the key basis for drug registration and marketing. once the data is falsified, the consequences will be disastrous.

the original report of southern weekend reads: “however, in china, fraud has long been rampant in this clinical trial process.”

around the same time, the economic information daily also published a report titled "80% of new drug data are fake, exposing the poor pharmaceutical ecosystem." what's surprising is that pharmaceutical companies still feel "wronged," believing that they can't use today's "opinions" and "regulations" to measure what they did in the past, and can't use the minimum drug standards to require them to comply with "national conditions."

could it be that pharmaceutical companies can fabricate data at will, and that pharmaceutical executives do not take their own "problematic drugs" but let ordinary people take them, which is their understanding of the "national conditions"?

of course, this was reported nearly ten years ago, and perhaps the relevant issues have been rectified over the years. in fact, it is not to say that domestically produced drugs are synonymous with inferior quality, but everyone knows that a single rat dropping spoils the whole barrel, not to mention that there are quite a few rat droppings in this barrel.

in a word, in order to increase the people's trust in domestically produced medicines, we must first improve the efficacy of domestically produced medicines. if other imported medicines score 90 points, your domestic medicines must score around 80 points, rather than having a huge gap. to improve the efficacy of domestically produced medicines, on the one hand, we must allow imported medicines to provide more sufficient competition, and we cannot allow inferior drugs to drive out good ones. on the other hand, supervision must have teeth, rather than repeatedly allowing the public to see that companies producing problematic drugs have gone public again and officials who have committed dereliction of duty have been promoted again.