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Written by | Song Wenfa

cancerIt is a major public health issue in the world. In recent years, due to factors such as diet, environment, and an aging population, the global incidence of cancer has continued to increase, and cancer has become increasingly prominent as a major cause of death.

In order to reduce the risk of various chronic diseases, in 2010, the American Heart Association（AHA）Launched a cardiovascular health guide（LS7）In 2022, the American Heart Association Circulation The journal published updated cardiovascular health guidelines, which include sleep as part of the guidelines.8 indicators necessary for life（LE8）”。

Specifically,LE8 includes: exercise, healthy diet, no smoking, healthy sleep, healthy weight, blood pressure, blood lipids and blood sugar。

Cancer and cardiovascular disease are common health problems, and there is evidence that cancer and cardiovascular disease share common lifestyle risk factors. However, it is unclear whether LE8, which is used to assess cardiovascular disease, can predict cancer risk and mitigate the impact of genetic factors on cancer.

August 10, 2024Tianjin Medical Universityof researchers inAmerican Journal of Clinical Nutritionpublished an article entitled " Cardiovascular Health，Polygenic Risk Score and Cancer Risk：A Prospective Cohort Study "Research paper.

Research shows thatRegardless of genetic risk, adherence to the cardiovascular health marker LE8 was associated with a significantly lower risk of overall cancer and most common cancers。

Specifically, higher scores on the cardiovascular health indicator LE8 were associated with a lower risk of overall cancer and 11 site-specific cancers, including digestive system cancers.(34-67% reduction), lung cancer(75% reduction), Kidney cancer (58% reduction), bladder cancer(45% reduction), breast cancer(17% decrease)and endometrial cancer(61% reduction)。

It is worth noting that regardless of genetic risk, the risk of the above cancers can be reduced by cardiovascular health indicators, except for gastric cancer, liver cancer and breast cancer.

In this study, the researchers analyzed UK Biobank The 277,002 participants in the database, aged between 37 and 73 years old, were scored based on the LE8 index, ranging from 0 to 100 points, with higher scores indicating better cardiovascular health. The genetic risk of 18 cancers was also calculated based on genotyping and single nucleotide polymorphisms.（PRS）, analyzed the associations between cardiovascular health markers and genetic risk with overall and site-specific cancer risk.

According to the AHA's evaluation criteria for cardiovascular health indicators, LE8 scores are divided into: low（<50）,medium（50-80）,high（≥80）. And according to PRS, genetic susceptibility is divided into low, medium and high.

During an average follow-up of 12 years, a total of 33,261 participants developed new cancers, of which 15.3% had low LE8 scores, 12.23% had medium scores, and 9.2% had high scores. There were significant differences in cancer incidence among the three score groups.

Analysis of LE8 scores revealed thatThe higher the LE8 score, the lower the overall cancer risk. For every 10-point increase in the LE8 score, the risk of overall cancer and 11 specific site cancers decreased by 6-32%.。

Compared with the low LE8 score group, the high LE8 score group was associated with a 67% lower risk of digestive system cancers and a 75% lower risk of lung cancer in a dose-response relationship. It also reduced the risk of kidney cancer.(58% reduction), bladder cancer(45% reduction), breast cancer(17% decrease)and endometrial cancer(61% reduction)risk.

Analysis of genetic risk found that people with medium and high genetic risk were more likely to develop cancer than those with low genetic risk.

The joint analysis found thatParticipants with high genetic risk and low LE8 scores had the highest cumulative incidence of overall cancer, whereas participants with low genetic risk and high LE8 scores had the lowest overall cancer incidence.。

Compared with the low LE8 score group,Regardless of genetic risk, high LE8 scores were associated with a reduced overall cancer risk, with the lowest risk in the low genetic risk group.In addition, for overall cancer in men, there was an interaction between LE8 score and genetic risk.

For site-specific cancers, regardless of genetic risk, a high LE8 score was associated with a reduced risk of esophageal, lung, kidney, and endometrial cancers.

Conclusions: Regardless of genetic risk, a high LE8 score was associated with a lower risk of overall cancer and 11 site-specific cancers. The results emphasize that cardiovascular health indicators are important not only for cardiovascular disease prevention but also for primary prevention of cancer.

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