2024-10-07
한어Русский языкEnglishFrançaisIndonesianSanskrit日本語DeutschPortuguêsΕλληνικάespañolItalianoSuomalainenLatina
the karolinska institute in sweden announced today that the 2024 nobel prize in physiology or medicine will be awarded to scientists victor ambros and gary ruvkun for their discovery of microrna and its post-transcriptional role. role in gene regulation.
microrna (mirna) is a type of endogenous non-coding rna. they play an important role in regulating gene expression and are related to the pathogenesis of many malignant diseases. they play an important role in the early detection, tumor classification and staging treatment of cancer. effect. accurate and sensitive detection of cancer marker microrna is of great research significance to human health.
in 1993, ambrose and rufkun published their research results on lin-4 (the first mirna) back-to-back in the journal cell. ambrose discovered that lin-4 exists in c. elegans, and rufkun confirmed that this mirna regulates the translation of target genes by binding to their messenger rna. this discovery initially did not attract widespread attention in the academic community until the rufkun laboratory discovered the second mirna let-7 in 2000. this discovery confirms that regulatory small rnas discovered by ambrose in 1993 are a type of single-stranded rna molecules with conserved functions that are widely present in species and may play an important expression regulatory mechanism.
in 2006, two scientists missed out on the nobel prize. at that time, the nobel prize in physiology or medicine was awarded to andrew fire and craig mello for their contributions in the field of rnai. contribution. despite this, ambrose and rufkun's discoveries opened up a new perspective for gene regulation research, and their research was hailed as the "nobel prize pearl" by the industry because of its great value.
the nobel prize in physiology or medicine will be awarded at a ceremony in stockholm on december 10, when ambrose and rufkun will receive the honor along with other nobel laureates.
collect and organize the latest news information and make it free for everyone to check.
