news

한어Русский языкEnglishFrançaisIndonesianSanskrit日本語DeutschPortuguêsΕλληνικάespañolItalianoSuomalainenLatina

american researchers recently published a paper in the latest issue of the american journal science immunology, saying that animal experiments have found thata dose of aids vaccine administered twice in an appropriate manner produces a much higher immune effect than a single vaccination, which is equivalent to a complex 7-dose vaccination regimen.

hiv mutates very quickly, and a single vaccination is often not effective. previous studies have found that seven vaccinations every other day, with increasing doses, can significantly enhance the effectiveness of the vaccine, but this plan is too complicated to be implemented on a large scale in practice.

△data map

researchers at the massachusetts institute of technology in the united states used an antigen designed based on the hiv envelope glycoprotein and combined it with a nanoparticle adjuvant to make a vaccine.multiple vaccination regimens with different times, dosage ratios, and time intervals were tried on mice.。

the results showed that the first vaccination of 20% of the dose, followed by the remaining 80% a week later, could achieve the same effect as seven vaccinations. compared with a single vaccination, the follicular helper t cell response increased by 6 times, the b cells that produce immune memory increased by 10 times, and the antibody response in the serum was 60 times higher.

computer simulation analysis found that a low-dose first vaccination can prepare the immune system so that it can operate efficiently after the second vaccination, produce antibodies, and form immune memory. the researchers said,reducing 7 vaccinations to 2 greatly improves clinical feasibility。

the research team will next conduct experiments on primates and try to use sustained-release technology in the second vaccination to gradually release the antigen to further enhance the immune response.