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In recent years, under the combined influence of multiple factors such as life pressure, bad living habits, environment and advanced childbearing, the incidence of recurrent pregnancy loss (such as repeated spontaneous abortion, fetal arrest, recurrent biochemical pregnancy, etc.) has gradually increased.

In patients with recurrent pregnancy loss, blocking antibodies are often absent, meaning their blocking antibody tests are often negative.

01. What are blocking antibodies? Why do blocking antibodies need to be positive?

The so-called "blocking antibodies" are simply a type of protective antibody produced by the mother after she comes into contact with the father's antigen during normal pregnancy.

As we all know, an embryo is formed by the combination of the mother's egg and the father's sperm, and carries half of its genetic material from the mother and half from the father. However, as the main body of the embryo, the mother will reject the "father's genetic material" during the embryo's implantation and development. That is, the immune system will launch an immune attack on the embryo.Blocking antibody positive, this attack will be blocked, and the embryo will be able to implant successfully and develop into a full-term fetus. On the contrary, that is, when the blocking antibody is negative, it will be prone to miscarriage or even habitual miscarriage.