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On August 11, as one of the featured forums of the 2024 SIP Conference, the first Health Industry Outlook Forum opened in Boao, Hainan. Starting from the macro trend of the global health industry, the forum closely discussed the cutting-edge dynamics and future trends of life sciences, and analyzed the direction of investment and R&D in the health industry.

The forum brought together many top scientists and industry leaders from home and abroad, including Li Jinsong, an academician of the Chinese Academy of Sciences, Yin Hao, deputy director of Shanghai Changzheng Hospital, and Ng Lai Guan, a senior researcher at Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine.

The content preview is a highlight. The rapid development of cutting-edge technologies such as artificial intelligence, gene editing, and synthetic biology has greatly broadened the boundaries of human cognition of health. Can we stop ourselves from aging? How are microorganisms and immune regulation used to treat diseases? What are the cutting-edge developments in global life sciences such as the Human Genome Project? What are the future application scenarios of interdisciplinary subjects such as synthetic biology? How can basic research and applied research be effectively linked? How to reduce the cost of trial and error and accelerate the implementation of AI applications? These questions were revealed one by one at this preview forum.

Innovation tracks attract attention. The field of life sciences is experiencing unprecedented changes. What is the current level of R&D strength and industry scale, and where will it go in the future? Which innovation tracks have more prospects? Many industry leaders directly addressed hot topics, discussed "N methodologies for sustainable development of the industry", and held roundtable discussions on how to create a scientific research ecological environment suitable for the development of life sciences, as well as the trend of combining production and research in life sciences under the guidance of technology and demand. Their pioneering views were applauded several times by the participants.

Against the backdrop of a deeply aging population, technological innovation, and national development transformation, China's health industry has a huge incremental space. Wu Han, chairman of the SIP Conference and chairman of Zhongkang Technology, mentioned in his speech that innovation is the first element in the development of the health industry. Innovation here refers not only to the innovation of technology and drugs, but also to the innovation of corporate strategic thinking. The Prospective Forum targets major national and industrial needs, and from the four dimensions of new ideas, new research, new applications, and new investments, it aims to create a TED show platform for cutting-edge technology and industry hotspots in the health field, and is committed to enabling industry people to understand innovative technology more efficiently and investors to reach potential tracks more quickly.

New ideas and new mechanisms: the most cutting-edge innovation no-man’s land

In the vast ocean of life sciences, every tiny discovery may bring about a magnificent revolution. They are like explorers who go deep into the unknown jungle and advance into the most cutting-edge innovation no-man's land.

The team led by Cai Shiqing, a senior researcher at the Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences, holding the "compass" of whole genome screening, discovered an unmarked "new world" in the anti-aging journey - a new anti-aging target gene, which turned on the "invisible switch" to delay aging.

NgLai Guan, a senior researcher at Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine, is fully exploring the unlimited immune potential of neutrophils and striving to maximize the precise guidance of neutrophils. This research has opened up a new path for immunotherapy, making neutrophils like the "smart first line of defense", which can not only serve as an indicator of immunity, but also accurately regulate immune function.

Xie Liwei, a researcher at the Institute of Microbiology, Guangdong Academy of Sciences, revealed for the first time the mysterious relationship between intestinal flora and skeletal muscle. By releasing the magical butyrate signal in the intestinal flora, he safeguarded the "youthfulness" of skeletal muscle, unlocking the unlimited potential of intestinal flora in the prevention of skeletal muscle aging and the treatment of muscle atrophy.

New strategies and new research: the hottest new quality productivity

The rapid development of science and technology has not only brought about major changes in medicine, but also stimulated a huge explosion of new productivity in the global health industry.

In the field of cell research, Li Jinsong, an academician of the Chinese Academy of Sciences and the Academy of Sciences for the Developing World, pioneered a method of gene editing using "sperm-like stem cells", successfully bred "mice without a father", and promoted the "Genome-Wide Tagging Project (GTP)", affixing "QR codes" to more than 20,000 human protein-coding genes, and single-handedly established the "Beidou" system for life sciences, enabling scientists to quickly identify the function of each protein, so that scientific research expeditions and disease treatment will no longer get lost.

The research team of Li Bin, distinguished professor of Shanghai Jiao Tong University and deputy director of scientific research at the Shanghai Institute of Immunology, focuses on the mechanism research and clinical transformation of immune regulatory T cells in the fields of autoimmunity, tumor immunity, transplant immunity and infection immunity, and is committed to promoting the theory and practice of personalized precision immunotherapy, maintaining immune homeostasis and promoting human health.

Lu Buxun, a professor at the School of Life Sciences of Fudan University, invented a "scavenger" compound in cells - a small molecule glue. It can selectively identify and adhere to pathogenic waste in cells, such as virus fragments, abnormal proteins, aging cells, etc., and remove them through the cell's own degradation machinery, autophagy, and recycle raw materials, bringing new hope for the treatment of Huntington's disease, non-alcoholic fatty liver disease and other intractable diseases.

In the field of bioengineering and AI, Yang Daichang, a professor at the School of Life Sciences of Wuhan University, pioneered the use of genetic engineering technology to implant the gene of human serum albumin into rice. This modified rice is like a protein factory, producing a large amount of human serum albumin during its growth, making it possible to reduce the dependence on plasma for disease treatment.

Hua Zichun, professor at the School of Life Sciences of Nanjing University and director of the School of Pharmacy of Xinxiang Medical College, carefully regulates microbial communities and reveals the potential connection between microbial communities and human health through vivid and interesting research examples, providing new strategies for the treatment of major and intractable diseases.

Wang Sheng, a researcher at the Center for Excellence in Molecular Cell Science of the Chinese Academy of Sciences, successfully transformed psilocybin in "poisonous mushrooms", eliminating its hallucinogenic effects while retaining its antidepressant effects, and developed a new antidepressant compound.

Guo Guoji, Qiushi Distinguished Professor at Zhejiang University and deputy director of the Institute of Hematology at Zhejiang University, has created the "strongest brain" for precision medicine, using AI to unlock the code of diseases, develop personalized treatment plans, and even gain insight into health risks in advance, allowing prevention to stay ahead of disease.

New treatments and new applications: the most amazing regenerative miracle

Regenerative medicine has created remarkable medical miracles in many fields.

Hui Lijian, a researcher at the Center for Excellence in Molecular Cell Science of the Chinese Academy of Sciences, uncovered the mystery of the conversion between different types of cells, repeatedly studied the fine regulation of liver injury and regeneration, and pioneered new applications in the treatment of end-stage liver disease. Zuo Wei, a tenured professor at Tongji University School of Medicine and its affiliated Oriental Hospital, successfully achieved the regeneration of lung structure and function with his groundbreaking lung progenitor cell transplantation technology. He is now applying this breakthrough research to the field of kidney repair, exploring the potential and challenges of autologous renal progenitor cell transplantation in human kidney repair.