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it home reported on september 15 that the institute of modern physics of the chinese academy of sciences published a blog post yesterday (september 14), saying that its nuclear chemistry laboratory researcher qin zhi's team used the lanzhou heavy ion accelerator research facility (hirfl) toand the independently developed automated separation prototype system has made important progress in the simultaneous separation and preparation of medical isotopes radium-223 and actinium-225.

project background

as two highly promising alpha-emitting isotopes, radium-223 (half-life of 11.4 days) and actinium-225 (half-life of 10 days) have shown broad application prospects in the treatment of small tumors and multi-site metastatic cancers due to their unique physicochemical properties.

however, the traditional production methods of radium-223 and actinium-225 are complex and inefficient, which can hardly meet the growing demand. there is an urgent need to develop an efficient and automated preparation system.

project introduction

the team used the medium- and high-energy proton beams and nitrogen beams provided by the lanzhou heavy ion accelerator research facility.we independently developed and established an automated separation system that can simultaneously prepare radium-223 and actinium-225, and established a complete preparation process of "thorium target irradiation-separation and purification-drug labeling", significantly improving the separation and purification efficiency of radium-223 and actinium-225.

through automated separation and purification experiments, the research team successfully achieved the effective separation of hundreds of impurity nuclides. the separation recovery rate and radioactive purity of radium-223 and actinium-225 products were finally stabilized at 62% and 92%~96%, respectively.

the team also evaluated the changes in the radioactivity levels of the impurity nuclides actinium-226 and actinium-227 over time, and successfully carried out the synthesis research of the labeled compound 225ac-psma-617 using actinium-225 produced by the above process.