Written on World Lung Cancer Day: Salute to breakthrough therapy
2024-08-01
한어Русский языкEnglishFrançaisIndonesianSanskrit日本語DeutschPortuguêsΕλληνικάespañolItalianoSuomalainenLatina
▎WuXiangEdited by Kant Content Team
Editor’s Note:Lung cancer is one of the most deadly diseases in the world, with more than three people dying from it every minute, and about 1.8 million people losing their lives each year, accounting for 18% of cancer deaths worldwide, making it the leading cause of cancer death worldwide. For patients, lung cancer puts them under tremendous physical and psychological burdens, seriously reduces their quality of life, and their families also suffer heavy emotional and financial blows.
In the past decade, the treatment landscape of lung cancer has changed significantly. August 1 is World Lung Cancer Day. The theme of this year's World Lung Cancer Day is "Unity makes us stronger", deeply in line with the spirit of the global pharmaceutical industry - the entire industry has made tremendous progress in the development of innovative lung cancer therapies, changing the fate of countless families around the world and bringing hope of life to more people. On this special day today, the WuXi AppTec content team will review with you the landmark progress made by the industry in lung cancer treatment over the past decade, in order to pay tribute to the brave people who developed breakthrough therapies!
The emergence of precision therapy marks a major breakthrough in the treatment of lung cancer.By understanding the genetic mutations in a patient’s tumor, we can now tailor treatments that are more effective and less toxic than traditional chemotherapy.EGFRFor patients with non-small cell lung cancer with EGFR mutations, third-generation EGFR inhibitors such as Tagrisso (osimertinib) can target the T790M mutation, benefiting those patients who develop resistance after early EGFR inhibitor treatment.▲Some lung cancer drugs approved in the past decade (Image source: WuXi AppTec content team compiled and mapped based on public information)
Similarly, Alecensa (alectinib) is aALKIt has brought significant therapeutic effects to patients with gene-rearranged non-small cell lung cancer, shrinking tumors and delaying disease progression, bringing new hope to these lung cancer patients.Immunotherapy is another revolutionary breakthrough.Represented by Opdivo (nivolumab) and Keytruda (pembrolizumab), immunotherapy has changed the treatment landscape for many cancers, including lung cancer. By blocking the PD-1 pathway, these immunotherapies enable the immune system to more effectively identify and attack cancer cells, which can improve the survival rate of patients with advanced non-small cell lung cancer and extend their hope of life.Recently, another blockbuster drug, Enhertu (trastuzumab deruxtecan), has also been launched forHER2This therapy combines the advantages of targeted therapy and chemotherapy, reflecting the industry's continuous innovation and progress in the forefront of cancer treatment.Image source: 123RF
In addition to these drugs,New drug developers have also developed more innovative therapies to treat more patient groups.Some of these therapies inhibit cancer angiogenesis, while others targetKRASandROS1New or challenging targets such as these have enabled many patients who were previously untreatable to receive treatment, significantly prolonging their lives.
On this World Lung Cancer Day, we celebrate all the innovators.Your heroic efforts have brought real breakthroughs to patients around the world, turning despair into hope and transforming lung cancer, once a "death sentence," into a more manageable disease. In the process of empowering our global partners, we are constantly inspired by the changes that breakthrough therapies have brought to patients.While we celebrate these achievements, we must also acknowledge that the journey to conquer lung cancer is far from over.By maintaining the same spirit of innovation, collaboration and empathy for patients, the industry can continue to achieve extraordinary results.Together, we can createLet there be no difficult medicines or difficult diseases in the world"s future.Salute to the breakthrough therapy! Salute to the scientists! Salute to the global biopharmaceutical industry!References:
Disclaimer: WuXi AppTec's content team focuses on introducing the progress of global biomedical health research. This article is for information exchange purposes only. The views in this article do not represent WuXi AppTec's position, nor do they mean that WuXi AppTec supports or opposes the views in this article. This article is not a treatment plan recommendation. If you need guidance on treatment plans, please go to a regular hospital for treatment.
share，pointThumbs up，look in, focusing on global biomedical health innovation
