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On July 10, 2024, Professor Chen Yu, Director of the Heart Center of Anhui Provincial Second People's Hospital, successfully completed the first New Zealand rabbit carotid artery bypass model. This not only marks that the Heart Center Laboratory has made innovative breakthroughs in the province in animal model construction and has reached international standards, but also demonstrates the professional strength of the Heart Center Laboratory of Anhui Provincial Second People's Hospital in the field of cardiovascular disease research.

Separation of venous graft (upper left) Obtaining venous graft (upper right) Anastomosis of graft with proximal end (lower left) Anastomosis of graft with distal end (lower right)

Coronary artery bypass surgery is one of the important procedures to improve coronary blood supply. The main bypass material available to the human body is veins, but vein grafts are more prone to restenosis than arterial grafts, which has always been a difficult problem to be solved in clinical treatment. The research team of the Heart Center Laboratory is committed to in-depth research on the mechanism of vein graft restenosis through the New Zealand rabbit carotid artery bypass model and exploring effective mitigation strategies, striving to provide innovative insights on international cutting-edge issues such as vascular restenosis after vein graft bypass surgery.

The first New Zealand rabbit recovered after surgery (left) The second New Zealand rabbit recovered after surgery (right)

At present, the research work of the Heart Center Laboratory is progressing in an orderly manner. It has been able to successfully prepare animal models of common cardiovascular diseases such as myocardial infarction, heart failure, aortic dissection, and arterial bypass, and carry out related mechanism research. In the future, the Heart Center research team will continue to climb the peak of scientific research and contribute more academic voices from the "Provincial Second Hospital" to the field of cardiovascular disease research at home and abroad.